Endocrine Abstracts

Mammalian tissues are composed of heterogeneous populations of cells, interacting in highly structured microenvironments to achieve physiologic goals. Understanding the design principles of endocrine tissues organization requires approaches to analyze spatially-resolved sub-populations of cells within the tissue. The mammalian liver consists of hexagonal-shaped lobules, radially polarized by blood flow and morphogens. Key liver are differentially expressed along the lobule axi...

An 22-year-old patient with a history of homozygous sickle cell disease (complicated by multiple vaso-occlusive attacks) was referred to the endocrinologist for persistent hypercalcemia for more than one year (between 2.63 and 2.82 mmol/l, N: 2.15–2.50 mmol/l), associated with hypophosphoremia (0.71 mmol/l, N: 0.75–1.39 mmol/l) and elevation of parathyroid hormone (170 ng/l, N <49 ng/l). Cervical ultrasound did not show parathyroid adenoma, but parathyroid MIBI s...

Case: A 42-year old woman was referred to the endocrinology department for polydipsia and polyuria of sudden onset one month prior to presentation. She drank between 8 and 10 litres of water per day and complained of thirst, asthenia and lighter menstruation under her usual oral contraceptive pill. In addition to contraception she took 50 μg of L-thyroxine for Hashimoto thyroïditis. She had also a medical history of pink-red cutaneous lesions evolving for more than 1...

An 82-year-old woman with a history of breast carcinoma and hypertension underwent right laparoscopic adrenalectomy for a large mass (7×5 cm) of high density without contrast (>30 UH), non-secreting. Anatomapathological examination concluded to an adrenocortical adenoma without signs of malignancy: Weiss score of 2 and Ki67 <2%. Two years later, she developed polycythemia (Hb: 17.9 g/dl (N: 11.8–15.5); hematocrit: 53.5% (N: 35.3–46.1)) without involvemen...

Introduction: Hyperparathyroidism (HPT) during pregnancy is rare but requires a specific approach for its diagnosis HPT is associated with a high incidence of associated maternal, fetal and neonatal complications, including miscarriage (3,5x-fold higher than expected), IUGR, prematurity and pre-eclampsia(1,2,3). The severity of complications is proportional to degree of maternal calcium level.Case report: We report the c...

Background: Neuroendocrine malignancies are heterogeneous cancers with varied clinical outcomes. The molecular landscape driving this heterogeneity has not yet been fully characterized. We aimed to investigate the gene expression profiles of neuroendocrine neoplasms, in relationship to baseline clinicopathological features and clinical outcomes, to elucidate underlying biology and potential therapeutic targets.Methods: Patients with neuroendocrine tumors...

Objective: To evaluate the relation of mean platelet volume (MPV) levels with serum paraoxonase-1 activity in diabetic patients with respect to obesity and diabetic complications.Methods: A total of 201 diabetic patients grouped with respect to obesity obese (n=89) and non-obese (n=112) and diabetic complications with (n=50) or without (n=150) microvascular complications and with (n=91) or without (n=...

Introduction-aim: Non-alcoholic fatty liver disease (NAFLD) is a clinical condition of uncertain etiology, in whose pathogenesis several mechanisms are involved and which is defined by fat vacuoles in more than 5% of hepatic histiocytes in the absence of serious alcohol consumption. It is frequently comorbid with obesity and insulin resistance. However, NAFLD is also seen in non-obese individuals. The purpose of this study was to compare insulin resistance and metabolic parame...

Neonatal diabetes, is monogenic and can be due to different mutations. Here we report two patients with neoanatal diabetes, with two different mutations and treatments.Case 1 was a female infant of consanguineous parents born at 37 weeks of gestation with a birth weight of 1900 g. After birth she was followed for respiratory distress and hyperglycemia. Her blood glucose was controlled with glargine insulin and with rapid acting insulin when needed. Her p...

Aim: There is strong evidence regarding vitamin D being a risk factor for Type 2 Diabetes Mellitus (T2DM). In this study, we aimed to investigate the effects of vitamin D on advanced glycation end-products in prediabetic and type 2 diabetic patients with vitamin D deficiency.Methods: Forty type 2 diabetic patients, 40 prediabetic patients and 40 healthy controls with the levels of vitamin D <20 ng/ml were included in the study. All three groups were ...